Gaucherand P, Salle B, Sergeant P, Guibaud S, Brun J, Bizollon C A, Rudigoz R C
Service de Gynaécologie-Obstétrique, Hopital de la Croix-Rousse Lyon, France.
Acta Obstet Gynecol Scand. 1997 Jul;76(6):536-40. doi: 10.3109/00016349709024579.
To assess the diagnostic value of three vaginal markers-insulin-like growth factor binding protein 1 (= IGFBP1), diamine-oxidase (= DAO) and pH-for diagnosis of the premature rupture of membranes.
One hundred pregnant women participated in the study. They were divided into three groups: group A (34 cases with intact membranes), group B (35 cases with total rupture of the membranes), group C (31 cases of suspected rupture of the membranes). Each patient underwent three successive tests for each of the three markers. The test order was allocated at random. For pH the reaction is colorimetric, for DAO the reaction is radio-enzymatic and for IGFBP1 the reaction is immuno-chromatographic. All three reactions are qualitative in nature. The parameters studied were conventional statistical parameters (sensitivity = SN, specificity = SP, positive predictive value = PPV and negative predictive value = NPV).
The analysis of the statistics gave the following results in percentages for SN, SP, PPV and NPV respectively; pH: 90.7%, 77.2%, 75%, 91.7%. DAO: 83.7%, 100%, 100%, 89%. IGFBP1: 95.3%, 98.2%, 97.6%, 96.5%.
The determination of variations in pH is not satisfactory. IGFBP1 is at least better than DAO with, additionally, advantages of rapidity and simplicity.
评估三种阴道标志物——胰岛素样生长因子结合蛋白1（=IGFBP1）、二胺氧化酶（=DAO）和pH值——对胎膜早破的诊断价值。
100名孕妇参与了该研究。她们被分为三组：A组（34例胎膜完整）、B组（35例胎膜完全破裂）、C组（31例疑似胎膜破裂）。每位患者对三种标志物中的每一种都进行了连续三次检测。检测顺序随机分配。对于pH值，反应是比色法；对于DAO，反应是放射酶法；对于IGFBP1，反应是免疫层析法。所有三种反应本质上都是定性的。所研究的参数是常规统计参数（敏感性=SN、特异性=SP、阳性预测值=PPV和阴性预测值=NPV）。
统计分析得出SN、SP、PPV和NPV的结果分别以百分比表示如下；pH值：90.7%、77.2%、75%、91.7%。DAO：83.7%、100%、100%、89%。IGFBP1：95.3%、98.2%、97.6%、96.5%。
pH值变化的测定结果不尽人意。IGFBP1至少比DAO更好，此外还具有快速简便的优点。
