Boffelli D, Compassi S, Werder M, Weber F E, Phillips M C, Schulthess G, Hauser H
Department of Biochemistry, Swiss Federal Institute of Technology, ETH Zentrum, Zürich.
FEBS Lett. 1997 Jul 7;411(1):7-11. doi: 10.1016/s0014-5793(97)00658-3.
The uptake of free and esterified cholesterol at the brush border membrane is protein-mediated. Here we show that this sterol uptake is effectively inhibited by exchangeable serum apolipoproteins. Binding of the apolipoprotein to the brush border membrane mediates the inhibitory effect. Evidence is presented to show that the structural motif responsible for the inhibition is the amphipathic alpha-helix.
游离胆固醇和酯化胆固醇在刷状缘膜的摄取是由蛋白质介导的。在此我们表明，这种甾醇摄取可被可交换血清载脂蛋白有效抑制。载脂蛋白与刷状缘膜的结合介导了这种抑制作用。有证据表明，负责这种抑制作用的结构基序是两亲性α-螺旋。
