来自冬眠大脑的某些肽对心脏细胞中钙离子电流及中隔神经元活性的影响。
The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons.
作者信息
Kokoz Y M, Zenchenko K I, Alekseev A E, Korystova A F, Lankina D A, Ziganshin R H, Mikhaleva I I, Ivanov V T
机构信息
Regulation of Ionic Currents Group, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region.
出版信息
FEBS Lett. 1997 Jul 7;411(1):71-6. doi: 10.1016/s0014-5793(97)00607-8.
The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca2+ current were studied. TSKYR activated Ca2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca2+ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca2+ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.
研究了从冬眠地松鼠大脑中分离出的肽TSKYR和DY对Ca2+电流的影响。TSKYR激活了青蛙心房纤维和青蛙心室单细胞中的Ca2+电流，而DY在这两种制剂中均阻断了Ca2+电流。在分离的大鼠和地松鼠心肌细胞中，TSKYR对Ca2+电流没有影响，而DY增加了Ca2+电流。在大鼠脑切片中，DY阻断了内侧隔核神经元的活性。TSKYR在初始阶段增加了隔核神经元的活性，随后神经元活性降低。
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