口服片剂和膏剂形式的抗生素后头孢氨苄在猫体内的药代动力学。
Pharmacokinetics of cephalexin in cats after oral administration of the antibiotic in tablet and paste preparations.
作者信息
Thornton J R, Martin P J
机构信息
Division of Companion Animal Clinical Sciences, School of Veterinary Science, University of Queensland.
出版信息
Aust Vet J. 1997 Jun;75(6):439-40. doi: 10.1111/j.1751-0813.1997.tb14350.x.
OBJECTIVE
To determine the bioequivalence of a paste formulation of cephalexin with that of the tablet form.
DESIGN
A two-way cross-over study.
ANIMALS
Ten adult cats of mixed breed.
PROCEDURE
The cats, randomly allocated to two groups, received either the paste preparation or the tablet orally at 12-hour intervals for 48 h before a 12-hour blood collection period. Two weeks later the treatments were reversed and the blood sampling repeated. The serum concentrations of the antibiotic were determined. The pharmacokinetic factors were analysed using a computer.
RESULTS
There were no significant differences between the peak concentration of cephalexin, or the other pharmacokinetic factors obtained from the tablet and paste formulations. The serum profiles of cephalexin following four 12-hourly doses of each formulation were similar with the peak serum values occurring at approximately 2 h after administration.
CONCLUSION
The paste formulation and the tablet form are bioequivalent.
目的
确定头孢氨苄糊剂制剂与片剂制剂的生物等效性。
设计
双向交叉研究。
动物
十只成年杂种猫。
实验步骤
将猫随机分为两组，在12小时的采血期前48小时，每隔12小时口服糊剂制剂或片剂。两周后，治疗方法互换并重复采血。测定抗生素的血清浓度。使用计算机分析药代动力学因素。
结果
头孢氨苄的峰值浓度或从片剂和糊剂制剂获得的其他药代动力学因素之间没有显著差异。每种制剂每12小时给药四次后头孢氨苄的血清曲线相似，血清峰值出现在给药后约2小时。
结论
糊剂制剂和片剂具有生物等效性。
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