Deuschle M, Schweiger U, Standhardt H, Weber B, Heuser I
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany.
Psychoneuroendocrinology. 1996 Nov;21(8):645-9. doi: 10.1016/s0306-4530(96)00033-9.
We studied corticosteroid-binding globulin (CBG) in 25 drug-free depressed patients and 33 healthy controls over a wide age-range. CBG was measured at 0800, 1400, 2000 and 2400 h in all subjects. Analysis of variance (ANOVA) with repeated measurement design revealed a significant effect of gender and time, but not of diagnosis (depressed patients vs healthy controls) or age group (< 50/> 50 years). In females, regardless of diagnosis, CBG plasma concentrations were significantly increased, when compared with their male counterparts. Although as a group depressed patients had significantly higher plasma cortisol concentrations (108.0 +/- 23.1 vs 70.7 +/- 10.9 micrograms/l), CBG levels did not differ between the two groups. Thus we did not find hypercortisolemia in depression to be paralleled by a decrease in CBG. However, the exaggerated activity of the hypothalamus-pituitary-adrenocortical system in healthy and depressed females is associated with an increase in plasma CBG.
我们在25名未服用药物的抑郁症患者和33名年龄范围广泛的健康对照者中研究了皮质类固醇结合球蛋白（CBG）。在所有受试者的08:00、14:00、20:00和24:00测量CBG。采用重复测量设计的方差分析（ANOVA）显示性别和时间有显著影响，但诊断（抑郁症患者与健康对照者）或年龄组（<50岁/>50岁）没有显著影响。在女性中，无论诊断如何，与男性相比，血浆CBG浓度显著升高。尽管作为一个群体，抑郁症患者的血浆皮质醇浓度显著更高（108.0±23.1对70.7±10.9微克/升），但两组之间的CBG水平没有差异。因此，我们没有发现抑郁症患者的高皮质醇血症与CBG降低同时出现。然而，健康女性和抑郁症女性下丘脑-垂体-肾上腺皮质系统的过度活动与血浆CBG升高有关。
