Baud H, Betencourt A, Peyre M, Penasse L
J Antibiot (Tokyo). 1977 Sep;30(9):720-3. doi: 10.7164/antibiotics.30.720.
A mutant of a neomycin-producting Streptomyces fradiae was found which synthesizes ribostamycin instead of neomycin. After a reverse mutation new colonies were obtained producting neomycin again. Ribostamycin might thus be considered as an intermediate in the biosynthesis of neomycin.
发现一种生产新霉素的弗氏链霉菌突变体,它合成核糖霉素而非新霉素。经过回复突变后,再次获得了产生新霉素的新菌落。因此,核糖霉素可被视为新霉素生物合成的中间体。