Paoletti S, Gilli R, Navarini L, Crescenzi V
Institute of Biochemistry, University of Sassari, Italy.
Glycoconj J. 1997 Jun;14(4):513-7. doi: 10.1023/a:1018515905407.
The study of the proton dissociation process of weak polyacids (eg a carboxylic poly(monoprotic)acid) is based on the knowledge of the change in electrostatic free energy, G(el), as a function of the variation of the number of charges on the polymer chain. The original treatment proposed by Manning can be used to describe the proton dissociation process of weak poly(monoprotic)acids, in the absence of pH-induced conformational transitions. In order to describe the alpha dependence of pKa of weak co-poly(monoprotic)acids containing two different acidic groups in different amounts along the polymer chain, a simple modification of the model is proposed.
对弱多元酸（如羧基聚（单质子）酸）质子解离过程的研究基于静电自由能G(el)随聚合物链上电荷数变化的相关知识。在不存在pH诱导的构象转变的情况下，Manning提出的原始处理方法可用于描述弱聚（单质子）酸的质子解离过程。为了描述沿聚合物链含有不同数量两种不同酸性基团的弱共聚（单质子）酸的pKa对α的依赖性，提出了对该模型的一种简单修正。
