Holycross B J, Summers B M, Dunn R B, McCune S A
College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA.
Am J Physiol. 1997 Jul;273(1 Pt 2):H228-33. doi: 10.1152/ajpheart.1997.273.1.H228.
Plasma renin activity (PRA) increases during heart failure; however, PRA is altered by drug therapy, and it is difficult to study the natural progression of elevated PRA in humans and the possible factors that contribute to its rise. This study evaluated PRA in a drug-naive hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting in heart failure (HF). Mean arterial blood pressure and PRA were determined and correlated to heart weight index in conscious normotensive, spontaneously hypertensive rats and HF rats of various ages. PRA, atrial natriuretic peptide, and aldosterone levels progressively increase with age in male HF rats. PRA and blood pressure are independently correlated to cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was elevated in spontaneously hypertensive compared with normotensive rats. Female HF rats have elevated PRA, but the increase is temporally delayed compared with that in male HF rats. Hypertension, PRA, and male gender are independent factors contributing to cardiac hypertrophy and heart failure in the HF model. The HF rat model may prove useful in determining the contribution of these factors in the progression from cardiac hypertrophy to heart failure.
血浆肾素活性（PRA）在心力衰竭期间会升高；然而，PRA会受到药物治疗的影响，因此很难研究人类PRA升高的自然进程以及导致其升高的可能因素。本研究在一种未经药物治疗的高血压大鼠模型（SHHF/Mcc-facp）中评估了PRA，该模型具有导致心力衰竭（HF）的遗传程序。在清醒的正常血压、自发性高血压大鼠以及不同年龄的HF大鼠中，测定了平均动脉血压和PRA，并将其与心脏重量指数进行关联。雄性HF大鼠的PRA、心房利钠肽和醛固酮水平随年龄增长而逐渐升高。在雄性HF大鼠中，PRA和血压与心肌肥厚独立相关。与正常血压大鼠相比，自发性高血压大鼠的心房利钠肽升高。雌性HF大鼠的PRA升高，但与雄性HF大鼠相比，升高出现的时间延迟。高血压、PRA和雄性性别是导致HF模型中心肌肥厚和心力衰竭的独立因素。HF大鼠模型可能有助于确定这些因素在从心肌肥厚发展到心力衰竭过程中的作用。
