Mymryk J S, Smith M M
Department of Microbiology and University of Virginia Cancer Center, School of Medicine, University of Virginia, Charlottesville 22908, USA.
Biochem Cell Biol. 1997;75(2):95-102.
In the eukaryotic nucleus, compaction of DNA into chromatin can limit the access of trans-acting factors, providing an additional level of regulation to processes such as transcription, replication, and repair. Recent studies have suggested that the protein products of the adenovirus 5 E1A oncogene can influence SWI-SNF and histone acetylase activities, two cellular processes that facilitate transcription in the context of chromatin. This review focuses on the unexpected effects of E1A on cellular processes that remodel chromatin in relation to its transcriptional and transforming activities.
在真核细胞核中，DNA压缩成染色质会限制反式作用因子的接近，为转录、复制和修复等过程提供额外的调控水平。最近的研究表明，腺病毒5 E1A癌基因的蛋白质产物可影响SWI-SNF和组蛋白乙酰化酶活性，这两个细胞过程在染色质环境中促进转录。本综述重点关注E1A对与转录和转化活性相关的染色质重塑细胞过程的意外影响。
