Ottenhoff T H, Spierings E, Nibbering P H, de Jong R
Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands.
Int Arch Allergy Immunol. 1997 Aug;113(4):400-8. doi: 10.1159/000237615.
Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vaccination strategies as well as novel immunomodulating regimens are warranted for the control of morbidity and mortality in mycobacterial diseases. Since CD4+ Th1 cells and type-1 cytokines play a key role both in protective immunity and immunopathology in mycobacterial infections, we here describe new pharmacological and cytokine-based strategies to regulate Th1 immunity.
分枝杆菌感染是全球医疗保健面临的主要问题。结核病尤其令人担忧，因为其死亡率很高，而在麻风病中，免疫病理学的发生，尤其是神经损伤，是一个主要问题，因为杆菌本身相对无害。因此，为了控制分枝杆菌病的发病率和死亡率，有效的疫苗接种策略以及新型免疫调节方案都是必要的。由于CD4+ Th1细胞和1型细胞因子在分枝杆菌感染的保护性免疫和免疫病理学中都起着关键作用，我们在此描述调节Th1免疫的新的药理学和基于细胞因子的策略。
