餐后（食物依赖型）运动诱发过敏反应中嗜酸性粒细胞衍生蛋白
Eosinophil-derived proteins in postprandial (food-dependent) exercise-induced anaphylaxis.
作者信息
Romano A, Fanales-Belasio E, Di Fonso M, Giuffreda F, Palmieri V, Zeppilli P, Ansotegui I J, Venuti A, Paganelli R, Aiuti F
机构信息
Department of Internal Medicine and Geriatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Int Arch Allergy Immunol. 1997 Aug;113(4):505-11. doi: 10.1159/000237629.
BACKGROUND
Postprandial exercise-induced anaphylaxis (PPEIAn) is a form of EIAn in which the ingestion of food before the exercise is associated with the onset of symptoms. Skin reactivity and the presence of specific serum IgE to several food allergens suggest the occurrence of food-dependent allergic mechanisms.
METHODS
In order to study the involvement of eosinophils in the pathogenesis of PPEIAn we measured the changes in serum eosinophil cationic protein (ECP) and eosinophil protein X/eosinophil-derived neurotoxin (EPX/EDN) levels in 6 patients with PPEIAn, subjected to three separate challenges with either suspected foods only, exercise after a meal without or with suspected food ingestion.
RESULTS
We found serum levels of both eosinophil-derived proteins increased only in challenges including both exercise and suspected food ingestion. Symptoms of anaphylaxis occurred in 3 of these patients.
CONCLUSIONS
The increased release of eosinophil basic proteins in PPEIAn patients, caused by physical exercise following ingestion of suspected foods, is not obligatory for the definition of the syndrome.
背景
餐后运动诱发的过敏反应（PPEIAn）是运动诱发过敏反应（EIAn）的一种形式，其中运动前摄入食物与症状发作有关。皮肤反应性以及针对几种食物过敏原的特异性血清IgE的存在提示了食物依赖性过敏机制的发生。
方法
为了研究嗜酸性粒细胞在PPEIAn发病机制中的作用，我们测量了6例PPEIAn患者血清嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒细胞蛋白X/嗜酸性粒细胞衍生神经毒素（EPX/EDN）水平的变化，这些患者分别接受仅用可疑食物、餐后运动但不摄入或摄入可疑食物后的三种不同激发试验。
结果
我们发现，仅在包括运动和摄入可疑食物的激发试验中，两种嗜酸性粒细胞衍生蛋白的血清水平均升高。其中3例患者出现过敏反应症状。
结论
摄入可疑食物后进行体育锻炼导致PPEIAn患者嗜酸性粒细胞碱性蛋白释放增加，并非该综合征定义的必要条件。
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