Merello M, Hughes A, Colosimo C, Hoffman M, Starkstein S, Leiguarda R
Movement Disorders Section, Institute for Neurological Research, Raul Carrea FLENI, Buenos Aires, Argentina.
Mov Disord. 1997 Jul;12(4):506-8. doi: 10.1002/mds.870120405.
Sleep benefit (SB) In Parkinson's disease (PD) is not well characterized. To determine SB frequency, as well as to characterize and correlate it with other disease variables, we evaluated prospectively a consecutive series of 312 PD patients by means of a structured questionnaire: 55% reported having SB and 35% reported that awakening was their best time of the day. Because of SB, 21% of the entire population were able to skip or delay medication. The mean duration of the phenomenon was 85.4 +/- 67 min. Patients with SB were significantly older (p < 0.0002), had disease longer (p < 0.05), and were often men (chi 2 = 3.5, df 1, p = 0.05). Patients with SB took sleep medication with similar frequency as those without SB. There were no differences in hours of sleep or sleep latency. Sleep problems such as nightmares or somnambulism, but not the number of sleep awakenings, were similar in both groups. In conclusion, SB is a frequent phenomenon, especially in men, elderly patients, and patients with longer disease duration. SB enables the morning L-dopa dose to be postponed in approximately 50% of patients.
帕金森病（PD）中的睡眠益处（SB）尚未得到充分描述。为了确定SB的频率，并对其进行特征描述以及与其他疾病变量进行关联分析，我们通过结构化问卷对连续的312例PD患者进行了前瞻性评估：55%的患者报告有SB，35%的患者报告醒来时是一天中状态最佳的时段。由于SB，21%的患者能够跳过或推迟用药。该现象的平均持续时间为85.4±67分钟。有SB的患者年龄显著更大（p<0.0002），病程更长（p<0.05），且男性居多（χ²=3.5，自由度1，p=0.05）。有SB的患者服用睡眠药物的频率与无SB的患者相似。两组在睡眠时间或睡眠潜伏期方面没有差异。两组的噩梦或梦游等睡眠问题相似，但睡眠觉醒次数不同。总之，SB是一种常见现象，尤其在男性、老年患者以及病程较长的患者中。SB使约50%的患者能够推迟早晨左旋多巴的剂量。
