Shome B, Parlow A F
J Clin Endocrinol Metab. 1977 Nov;45(5):1112-5. doi: 10.1210/jcem-45-5-1112.
For the first time the entire linear amino acid sequence of hPRL has been ascertained. The sequence features 198 amino acid residues, leucine at the NH2-terminus, and 6 half custines. hPRL sequence identity with porcine, ovine, and rat PRL is 77, 73, and 60%, respectively. However, hPRL sequence identity with hGH is only 16%, and with human placental lactogen 13%.
首次确定了人催乳素(hPRL)完整的线性氨基酸序列。该序列由198个氨基酸残基组成,氨基端为亮氨酸,还有6个半胱氨酸。hPRL与猪、羊和大鼠催乳素的序列同源性分别为77%、73%和60%。然而,hPRL与人生长激素(hGH)的序列同源性仅为16%,与人类胎盘催乳素的序列同源性为13%。