Lakhotia M, Shah P K, Yadav A, Gupta A, Modi R K, Sinha H V
Department of Internal Medicine DR. S.N. Medical College, Jodhpur (Rajasthan) India.
J Assoc Physicians India. 1996 Sep;44(9):612-4.
A comparison of various biochemical parameters used in differentiation of nature of pleural effusion in transudate and exudate was done in 84 patient of pleural effusion. Pleural fluid (P) cholesterol and bilirubin which have gained an importance in recent years were compared with pleural fluid protein, LDH, P/S protein, P/S LDH and Light's criteria. It was seen that Light's criteria is still the best in differentiation. Sensitivity of individual test was nearly same for Pl. protein (94.11%), P/S Protein (94.11%), Pl. LDH (95.5%), P/S LDH (92.75%). Pl cholesterol (88.3%) and P/S cholesterol (91.42%) had slightly lower sensitivity. Pl. Protein and P/S LDH had 100% specificity. Lights criteria had 100% specificity and sensitivity % of cases misclassified by various criteria were Pl Protein 5.95%, P/S protein 5.95%, PLDH 4.76%, P/S LDH 4.76% P. Cholesterol 13% and P/S Cholesterol 9.52% Measurement of Bilirubin did not provide any correlation in classifying the effusion and thus did not hold any value.
对84例胸腔积液患者进行了用于区分漏出液和渗出液性质的各种生化参数比较。将近年来受到重视的胸腔积液（P）胆固醇和胆红素与胸腔积液蛋白、乳酸脱氢酶、蛋白比值（P/S）、乳酸脱氢酶比值（P/S LDH）及Light标准进行了比较。结果发现，Light标准在鉴别方面仍是最佳的。各项检测的敏感度对于胸腔积液蛋白（94.11%）、蛋白比值（P/S）（94.11%）、胸腔积液乳酸脱氢酶（95.5%）、乳酸脱氢酶比值（P/S LDH）（92.75%）而言几乎相同。胸腔积液胆固醇（88.3%）和胆固醇比值（P/S）（91.42%）的敏感度略低。胸腔积液蛋白和乳酸脱氢酶比值（P/S LDH）具有100%的特异性。Light标准具有100%的特异性，各标准误诊病例的敏感度分别为：胸腔积液蛋白5.95%、蛋白比值（P/S）5.95%、胸腔积液乳酸脱氢酶4.76%、乳酸脱氢酶比值（P/S LDH）4.76%、胸腔积液胆固醇13%、胆固醇比值（P/S）9.52%。胆红素检测在积液分类中未显示任何相关性，因此没有任何价值。
