Sharma A K, Behari M, Ahuja G K
Neurology Department, All India Institute of Medical Sciences, New Delhi.
J Assoc Physicians India. 1996 Sep;44(9):645-7.
Fifty five patients with Meige's syndrome were examined for clinical and demographic features. The mean age of onset was 52.3 years. The peak age of onset was in the sixth decade with a male to female ratio of 1.11:1. The mean duration of illness was 3.7 years. Commonest initial symptom was increased blinking, seen in 30 cases (54.5%). Twenty five patients (45.4%) had complete syndrome of blepharospasm with oromandibular dystonia, whereas 24 patients (43.6%) had blepharospasm alone and the rest (6 patients, 10.9%) had oromandibular dystonia. The extension of spasm beyond cranial muscles was observed in 10 patients (18.1%). Eleven patients had family history of dystonia or other extrapyramidal disorders. Incidence of depression was high in these cases.
对55例Meige综合征患者进行了临床和人口统计学特征检查。平均发病年龄为52.3岁。发病高峰年龄在60岁，男女比例为1.11:1。平均病程为3.7年。最常见的初始症状是眨眼增多，30例（54.5%）出现此症状。25例（45.4%）患者出现眼睑痉挛合并口下颌肌张力障碍的完全综合征，而24例（43.6%）患者仅有眼睑痉挛，其余6例（10.9%）患者有口下颌肌张力障碍。10例（18.1%）患者痉挛扩展至颅外肌肉。11例患者有肌张力障碍或其他锥体外系疾病的家族史。这些病例中抑郁症的发生率较高。
