Taparia B N, Bahel B, Shah B V, Ashavaid T F, Kapadia A, Sirsat R A
Department of Nephrology; National Health and Education Society, Mahim, Bombay.
J Assoc Physicians India. 1996 Apr;44(4):240-2.
The present study is a retrospective chart analysis of 33 patients who satisfied the diagnostic criteria of multiple myeloma. Sixteen (49.5%) of these 33 patients developed renal failure at some point in time. The mean age +/- 1SD of patients who developed renal failure was 59.2 +/- 13 years (range 34-85 years). There were 12 males and 4 females. The precipitating factors for renal failure were dehydration (12.5%), hypercalcemia (62.5%) and use of non-steroidal antiinflammatory drugs (6.2%). Hypercalcemia was observed in 10 of the 16 patients who developed renal failure while it was seen in only 4 of the 17 cases who did not develop renal failure (relative risk 5.4). In 11 (68.7%) patients, the renal function improved with hydration, treatment of hypercalcemia and chemotherapy. The 1 and 3 year actuarial survival of patients with renal failure and multiple myeloma was 87% and 74% respectively.
本研究是对33例符合多发性骨髓瘤诊断标准患者的回顾性病历分析。这33例患者中有16例（49.5%）在某个时间点出现了肾衰竭。出现肾衰竭患者的平均年龄±1标准差为59.2±13岁（范围34 - 85岁）。其中男性12例，女性4例。肾衰竭的诱发因素为脱水（12.5%）、高钙血症（62.5%）和使用非甾体抗炎药（6.2%）。在出现肾衰竭的16例患者中有10例观察到高钙血症，而在未出现肾衰竭的17例患者中仅有4例出现高钙血症（相对风险5.4）。11例（68.7%）患者经补液、高钙血症治疗及化疗后肾功能得到改善。肾衰竭合并多发性骨髓瘤患者的1年和3年精算生存率分别为87%和74%。
