Sharada B, Wasir H S
Department of Cardiology, All India Institute of Medical Sciences, New Delhi.
J Assoc Physicians India. 1996 Apr;44(4):269-72.
Graft atherosclerosis in the transplant heart is essentially asymptomatic due to denervation of the transplant heart and also is rapidly progressive. After one year it is the major cause of transplant rejection. Histopathologically, graft atherosclerosis differs from the conventional atherosclerosis. Intra-vascular ultrasound and repeated coronary angiography help in its early diagnosis. Angioplasty and bypass graft surgery are not of much help. Preventive measures through dietary means to keep triglycerides under control and prophylactic use of calcium channel blocker, diltiazem are rewarding. Many patients with graft coronary atherosclerosis end up with retransplant.
由于移植心脏去神经支配，移植心脏中的移植物动脉粥样硬化基本无症状，且进展迅速。一年后，它是移植排斥的主要原因。在组织病理学上，移植物动脉粥样硬化与传统动脉粥样硬化不同。血管内超声和重复冠状动脉造影有助于早期诊断。血管成形术和搭桥手术帮助不大。通过饮食手段控制甘油三酯的预防措施以及预防性使用钙通道阻滞剂地尔硫卓是有效果的。许多患有移植物冠状动脉粥样硬化的患者最终需要再次移植。
