Roger M, Levee G, Chanteau S, Gicquel B, Schurr E
Center for the Study of Host Resistance, Montreal General Hospital Research Institute, Quebec, Canada.
Int J Lepr Other Mycobact Dis. 1997 Jun;65(2):197-202.
In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three physically linked, polymorphic microsatellite markers-D2S104, D2S173 and D2S1471-were also typed. Linkage analyses were done using affected sibpair and LOD score methods employing different modes of inheritance with full and reduced penetrance. The results of this study strongly suggest that NRAMP1 is not linked to leprosy susceptibility in the French Polynesian families tested.
为了确定小鼠抗分枝杆菌候选基因的人类同源基因（NRAMP1）是否影响人类疾病易感性，我们分析了来自法属波利尼西亚七个多病例麻风病家族（84人）的数据，以研究NRAMP1基因内的连锁标记与麻风病本身的关系。对各个家庭成员在NRAMP1内的九个多态性位点进行了分型。此外，还对三个物理连锁的多态性微卫星标记——D2S104、D2S173和D2S1471进行了分型。使用患病同胞对和对数优势计分法，采用不同的遗传模式及完全和降低的外显率进行连锁分析。本研究结果强烈表明，在测试的法属波利尼西亚家族中，NRAMP1与麻风病易感性无关。
