Foulkes W D, Buu P N, Filiatrault D, Leclerc J M, Narod S A
Department of Medicine, McGill University, Montréal, Québec, Canada.
Med Pediatr Oncol. 1997 Oct;29(4):272-9. doi: 10.1002/(sici)1096-911x(199710)29:4<272::aid-mpo7>3.0.co;2-j.
Neuroblastoma is one of the most common cancers of childhood. Some studies have shown an excess of congenital abnormalities in children who have been diagnosed with neuroblastoma. In this study we examined the medical records of all children with neuroblastoma seen at St. Justine Children's Hospital between the years 1977 and 1993. A total of 141 children (131 of French-Canadian ancestry) were included in this study. Twelve children (8.5%) had 21 defined congenital abnormalities (1,490 per 10,000 children). This compared with a rate of 444.3 children with abnormalities per 10,000 live births (4.44%) for all congenital abnormalities in the British Columbia Health Surveillance Registry, 1979-1988 (relative risk = 1.91, P = 0.03). Six of the 12 children had cardiovascular malformations. These and previous results suggest that there may be a common developmental origin to neuroblastoma and to some congenital malformations. Genes that control development may be worthy of further study in these children.
神经母细胞瘤是儿童期最常见的癌症之一。一些研究表明，被诊断患有神经母细胞瘤的儿童先天性异常过多。在本研究中，我们查阅了1977年至1993年间在圣贾斯汀儿童医院就诊的所有神经母细胞瘤患儿的病历。本研究共纳入141名儿童（131名法裔加拿大血统）。12名儿童（8.5%）有21种明确的先天性异常（每10000名儿童中有1490例）。相比之下，1979 - 1988年不列颠哥伦比亚省健康监测登记处所有先天性异常的发生率为每10000例活产中有444.3名儿童有异常（4.44%）（相对风险 = 1.91，P = 0.03）。12名儿童中有6名患有心血管畸形。这些结果以及之前的研究结果表明，神经母细胞瘤和某些先天性畸形可能有共同的发育起源。控制发育的基因可能值得在这些儿童中进一步研究。
