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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Novo Nordisk A/S, Health Care Discovery, Måløv, Denmark.

Gen Pharmacol. 1997 Aug;29(2):151-8. doi: 10.1016/s0306-3623(96)00417-x.

The L-2-amino-4-phosphonobutyric acid (L-AP4) receptor was originally discovered by the ability of L-AP4 to depress synaptic transmission in hippocampal glutamatergic pathways and in the retina. 2. The molecular identity of the L-AP4 receptor is not yet resolved; however, with the molecular cloning of subtypes of metabotropic glutamate receptors (mGluRs), high affinity targets for L-AP4 have been identified. 3. As the information on the pharmacology of the mGluRs and the electrophysiological and biochemical studies on L-AP4 receptor physiology becomes elaborated it seems evident that the L-AP4 receptor is not a single molecular target but may involve multiple receptor subtypes.

L-2-氨基-4-膦酰丁酸（L-AP4）受体最初是通过L-AP4抑制海马谷氨酸能通路和视网膜中突触传递的能力而被发现的。2. L-AP4受体的分子身份尚未明确；然而，随着代谢型谷氨酸受体（mGluRs）亚型的分子克隆，已确定了L-AP4的高亲和力靶点。3. 随着关于mGluRs药理学的信息以及对L-AP4受体生理学的电生理和生化研究不断深入，L-AP4受体似乎显然不是单一的分子靶点，而是可能涉及多种受体亚型。

Novo Nordisk A/S, Health Care Discovery, Måløv, Denmark.

Gen Pharmacol. 1997 Aug;29(2):151-8. doi: 10.1016/s0306-3623(96)00417-x.

The L-2-amino-4-phosphonobutyric acid (L-AP4) receptor was originally discovered by the ability of L-AP4 to depress synaptic transmission in hippocampal glutamatergic pathways and in the retina. 2. The molecular identity of the L-AP4 receptor is not yet resolved; however, with the molecular cloning of subtypes of metabotropic glutamate receptors (mGluRs), high affinity targets for L-AP4 have been identified. 3. As the information on the pharmacology of the mGluRs and the electrophysiological and biochemical studies on L-AP4 receptor physiology becomes elaborated it seems evident that the L-AP4 receptor is not a single molecular target but may involve multiple receptor subtypes.

L-2-氨基-4-膦酰丁酸（L-AP4）受体最初是通过L-AP4抑制海马谷氨酸能通路和视网膜中突触传递的能力而被发现的。2. L-AP4受体的分子身份尚未明确；然而，随着代谢型谷氨酸受体（mGluRs）亚型的分子克隆，已确定了L-AP4的高亲和力靶点。3. 随着关于mGluRs药理学的信息以及对L-AP4受体生理学的电生理和生化研究不断深入，L-AP4受体似乎显然不是单一的分子靶点，而是可能涉及多种受体亚型。