腺苷受体剂与条件性位置偏爱

Adenosine receptor agents and conditioned place preference.

Zarrindast M R, Moghadamnia A A

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.

Gen Pharmacol. 1997 Aug;29(2):285-9. doi: 10.1016/s0306-3623(96)00236-4.

Abstract

The effects of different doses of the adenosine agonists N5-ethylcarboxamido-adenosine (NECA), R-isomer of N6-phenylisopropyladenosine (R-PIA), and N6-cyclohexyladenosine (CHA) or of the antagonists theophylline and 8-phenyltheophylline (8-PT) on conditioned place preference (CPP) have been studied. 2. The results show that R-PIA and CHA induced conditioned place aversion (CPA) whereas NECA induced conditioned place preference (CPP). 3. Low doses of theophylline elicit CPP, but high doses of the drug induced CPA. 8-PT also produced the CPP. 4. The responses of R-PIA and CHA but not NECA was decreased by theophylline and 8-PT administration. 5. It is concluded that the induction of CPP an CPA by adenosine antagonsists may be mediated by different adenosine receptors.

摘要

研究了不同剂量的腺苷激动剂N5-乙基羧酰胺腺苷（NECA）、N6-苯基异丙基腺苷的R-异构体（R-PIA）和N6-环己基腺苷（CHA），或拮抗剂茶碱和8-苯基茶碱（8-PT）对条件性位置偏爱（CPP）的影响。2. 结果表明，R-PIA和CHA诱导条件性位置厌恶（CPA），而NECA诱导条件性位置偏爱（CPP）。3. 低剂量茶碱引发CPP，但高剂量该药物诱导CPA。8-PT也产生CPP。4. 给予茶碱和8-PT后，R-PIA和CHA的反应降低，但NECA的反应未降低。5. 得出结论，腺苷拮抗剂诱导CPP和CPA可能由不同的腺苷受体介导。