Castle D J, Wessely S, Howard R, Murray R M
Department of Psychological Medicine, Kings College Hospital London, UK.
Int J Geriatr Psychiatry. 1997 Jul;12(7):712-7.
To define the epidemiology, phenomenology, premorbid and risk factors in patients with the first manifestation of a schizophrenia-like illness after the age of 60 years, and compare them with patients with an onset before the age of 25 years.
DESIGN/SETTING/SUBJECTS: All contacts for a non-affective psychotic illness across all ages of onset were ascertained through a psychiatric case register; patients were rediagnosed according to operationalized criteria for psychotic illness, and those with a very early and very late onset compared.
Phenomenological, premorbid and aetiological parameters were compared in the two groups, using risk ratios and 95% confidence intervals.
Very late onset patients (N = 72) were, compared to their very early onset counterparts (N = 192), more likely to be female, have good premorbid functioning and development history, and to exhibit persecutory delusions and hallucinations; they were less likely to have negative schizophrenic symptoms, to have a positive family history of schizophrenia, or have suffered pregnancy or birth complications.
The results highlight premorbid, aetiological and phenomenological differences between patients with the onset of a schizophrenia-like illness at the extremes of adult life, and suggest it is premature to consider the two groups to be merely different manifestations of the same illness.
