Satoh K, Sakagami H, Motohashi N
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Anticancer Res. 1997 Jul-Aug;17(4A):2539-43.
12H-Benzo[a]phenothiazine generated radical(s) under alkaline conditions, and enhanced the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate. Phenothiazine and chlorpromazine hydrochloride did not produce radicals, nor affect the radical intensity of ascorbates. 12H-Benzo[a]phenothiazine scavenged the superoxide anion and hydroxyl radical, more efficiently than phenothiazine and chlorpromazine hydrochloride. The radical modulation activity of 12H-benzo[a]phenothiazine might explain at least in part the ability of this compound to induce monocytic differentiation and apoptosis in human myelogenous leukemic cell lines.
12H-苯并[a]吩噻嗪在碱性条件下产生自由基，并增强了抗坏血酸钠和5,6-亚苄基-L-抗坏血酸钠的自由基强度。吩噻嗪和盐酸氯丙嗪不产生自由基，也不影响抗坏血酸盐的自由基强度。12H-苯并[a]吩噻嗪清除超氧阴离子和羟基自由基的效率比吩噻嗪和盐酸氯丙嗪更高。12H-苯并[a]吩噻嗪的自由基调节活性可能至少部分解释了该化合物诱导人髓性白血病细胞系单核细胞分化和凋亡的能力。
