Novell F, Trias M, Molina R, Filella X
Service of Surgery, University of Barcelona, Hospital Clinic, Spain.
Anticancer Res. 1997 Jul-Aug;17(4A):2743-6.
About a 20-25% of the patients at diagnosis of colorectal carcinoma present with occult liver metastases. The aim of this work was to determine the prognostic significance of CEA bile level for the early detection of occult metastases. We determined the CEA blood level and the CEA bile level in 182 patients with colorectal carcinoma (3 Dukes' stage A, 86 Dukes' stage B, 53 Dukes' stage C, and 40 patients with liver metastases) and also in 42 patients with simple cholelithiasis, as the control group. In the patients with cholelithiasis, the mean values of CEA serum and bile levels were normal. In patients with colorectal carcinomas the CEA serum levels ranged from 3 to 110 ng/ml, and the CEA bile level from 3 to 226 ng/ml. Patients with liver metastases, had a mean CEA serum level of 193 ng/ml, while CEA bile level was 1,225 ng/ml. In conclusion, our results suggest that the determination of CEA bile is highly useful in the diagnosis of occult liver metastases.
约20%-25%的结直肠癌患者在确诊时已出现隐匿性肝转移。本研究的目的是确定癌胚抗原（CEA）胆汁水平对隐匿性转移早期检测的预后意义。我们测定了182例结直肠癌患者（3例杜克A期、86例杜克B期、53例杜克C期以及40例有肝转移的患者）的CEA血药浓度和CEA胆汁水平，还测定了42例单纯胆结石患者作为对照组。胆结石患者的CEA血清和胆汁水平均值正常。结直肠癌患者的CEA血清水平为3至110 ng/ml，CEA胆汁水平为3至226 ng/ml。有肝转移的患者CEA血清平均水平为193 ng/ml，而CEA胆汁水平为1225 ng/ml。总之，我们的结果表明，CEA胆汁检测对隐匿性肝转移的诊断非常有用。
