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Reference ranges for screening preclinical drug safety data.

作者信息

Amaratunga D

机构信息

R. W. Johnson Pharmaceutical Research Institute Rantan, New Jersey 08869-0602, USA.

出版信息

J Biopharm Stat. 1997 Jul;7(3):417-22. doi: 10.1080/10543409708835197.

DOI:10.1080/10543409708835197
PMID:9252834
Abstract

Reference ranges are used in preclinical drug safety studies to screen experimental data for atypical values. The methods used most often to construct sample reference ranges are essentially large sample methods and may flag too few "atypical" values. It is better to generate finite sample reference ranges by modifying existing methods used for constructing tolerance intervals. We define validity and efficiency for reference ranges and discuss the validity and efficiency of the methods described. A finite sample distribution-free method emerges as the clear winner.

摘要

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