Knobel B, Buyanowsky G, Dan M, Zaidel L
Department of Medicine B, Edith Wolfson Medical Center, Holon, Israel.
J Clin Gastroenterol. 1997 Jun;24(4):264-6. doi: 10.1097/00004836-199706000-00019.
Noncaseating granulomatous hepatitis may be caused by a variety of drugs, but we have not found, by computer search of the literature, a previous describe of granulomatous hepatitis associated with pyrazinamide. We describe a 52-year-old man with hectic fever, chills, extreme fatigue, liver damage, and hyperuricemia about 4 weeks after commencing pyrazinamide therapy. A liver biopsy specimen showed noncaseating epithelioid granulomas. The patient recovered soon after the interruption of tuberculostatic treatment.
非干酪样肉芽肿性肝炎可能由多种药物引起，但通过计算机检索文献，我们未发现之前有关于吡嗪酰胺相关肉芽肿性肝炎的描述。我们描述了一名52岁男性，在开始吡嗪酰胺治疗约4周后出现弛张热、寒战、极度疲劳、肝损伤和高尿酸血症。肝脏活检标本显示非干酪样上皮样肉芽肿。停用抗结核治疗后，患者很快康复。
