Bavbek S, Kalaycioglu O, Beder S, Misirligil Z
Ankara University, School of Medicine, Department of Allergy, Turkey.
J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):175-8.
Visual inspection of the airways in patients with chronic bronchitis and asthma by fiberoptic bronchoscopy and the relation of these findings to bronchoalveolar lavage (BAL) fluid analysis or some clinical parameters have been reported previously. In this study, we have attempted to assess and grade airway inflammation in allergic rhinitis patients (ARP) by fiberoptic bronchoscopy. During the procedure, BAL was obtained and visual inspection of airways done by the method used by Thompson et al. Ten ARP with bronchial hyperreactivity (BHR) (Group 1), 10 ARP without BHR (Group 2) and 2 nonatopic, healthy subjects (Control Group) were studied. The fluid recovery and differential cell concentration were similar in the three groups. The inflammatory scores were 11.0 +/- 7.0, 13.8 +/- 6.9, 15.0 +/- 4.2 in group 1, group 2 and control group, respectively, without showing any significant differences between the groups. There was no correlation between the inflammatory score and PC20 to methacholine. This indicates that BHR in ARP will need explanations other than the inflammation within airways.
先前已有报道通过纤维支气管镜对慢性支气管炎和哮喘患者的气道进行可视检查，以及这些检查结果与支气管肺泡灌洗（BAL）液分析或一些临床参数之间的关系。在本研究中，我们试图通过纤维支气管镜评估变应性鼻炎患者（ARP）的气道炎症并进行分级。在该过程中，获取BAL样本，并采用Thompson等人使用的方法对气道进行可视检查。研究了10例有支气管高反应性（BHR）的ARP患者（第1组）、10例无BHR的ARP患者（第2组）和2名非特应性健康受试者（对照组）。三组的液体回收率和细胞分类浓度相似。第1组、第2组和对照组的炎症评分分别为11.0±7.0、13.8±6.9、15.0±4.2，组间未显示出任何显著差异。炎症评分与乙酰甲胆碱PC20之间无相关性。这表明，ARP中的BHR需要从气道炎症以外的方面进行解释。
