中链甘油三酯乳剂在大鼠全肠外营养中对实验性肝转移的影响。

Effect of medium-chain triglyceride emulsion in total parenteral nutrition on experimental hepatic metastasis in the rat.

作者信息

Ohkawa A, Sato N, Hatakeyama K

机构信息

Department of Surgery, Niigata University School of Medicine, Japan.

出版信息

JPEN J Parenter Enteral Nutr. 1997 Jul-Aug;21(4):220-3. doi: 10.1177/0148607197021004220.

DOI:10.1177/0148607197021004220

PMID:9252948

Abstract

BACKGROUND

This study evaluated the effect of total parenteral nutrition (TPN) regimens containing a medium-chain triglyceride (MCT) emulsion on tumor metastasis.

METHODS

Tumor metastasis development was assessed by the number of metastatic foci on the liver surface in rats inoculated with ACL-15 tumor cells via the portal vein. Rats received one of the following TPN regimens: TPN containing an MCT emulsion (group M), in which tricaprylin emulsion served as the MCT and comprised 50% of nonprotein calories (NPC); TPN containing a long-chain triglyceride (LCT) emulsion (group L), in which soybean oil served as the LCT and comprised 50% of NPC; and TPN without lipid emulsion (group G), in which dextrose comprised 100% of NPC.

RESULTS

The number of metastatic foci was greatest in rats receiving TPN containing the MCT emulsion on day 11 after tumor cell inoculation and either 11 days of TPN or 2 days of TPN followed by 9 days standard rat chow.

CONCLUSIONS

TPN containing MCT emulsion increases liver metastasis early in its administration.

摘要

背景

本研究评估了含中链甘油三酯（MCT）乳剂的全胃肠外营养（TPN）方案对肿瘤转移的影响。

方法

通过经门静脉接种ACL - 15肿瘤细胞的大鼠肝脏表面转移灶数量来评估肿瘤转移的发展情况。大鼠接受以下TPN方案之一：含MCT乳剂的TPN（M组），其中三辛酸甘油酯乳剂作为MCT，占非蛋白热量（NPC）的50%；含长链甘油三酯（LCT）乳剂的TPN（L组），其中大豆油作为LCT，占NPC的50%；以及不含脂质乳剂的TPN（G组），其中葡萄糖占NPC的100%。