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癌症患者中的镰刀菌属所致真菌血症。

Fungaemia due to Fusarium spp. in cancer patients.

作者信息

Krcmery V, Jesenska Z, Spanik S, Gyarfas J, Nogova J, Botek R, Mardiak J, Sufliarsky J, Sisolakova J, Vanickova M, Kunova A, Studena M, Trupl J

机构信息

Department of Microbiology, Medicine, Chemotherapy and Haematology, National Cancer Institute, Bratislava, Slovak Republic.

出版信息

J Hosp Infect. 1997 Jul;36(3):223-8. doi: 10.1016/s0195-6701(97)90197-3.

Abstract

Five cases of fungaemia due to Fusarium spp. in cancer patients are described. Two were breakthrough cases, despite ongoing therapy with amphotericin B. Three were caused by Fusarium solani, one by F. oxysporum and one by F. dimerum. Four patients died, three of them despite therapy with amphotericin B for between 5-37 days. We describe only the second reported case of F. dimerum fungaemia. Since 1972, 93 cases of systemic infection with Fusarium spp. have been described: 43 had positive blood cultures and the overall mortality was 72%.

摘要

本文描述了5例癌症患者由镰刀菌属引起的真菌血症。其中2例为突破性感染,尽管患者正在接受两性霉素B治疗。3例由茄病镰刀菌引起,1例由尖孢镰刀菌引起,1例由双隔镰刀菌引起。4例患者死亡,其中3例尽管接受了5至37天的两性霉素B治疗仍死亡。我们仅描述了第二例报告的双隔镰刀菌真菌血症病例。自1972年以来,已描述了93例镰刀菌属的全身感染病例:43例血培养呈阳性,总体死亡率为72%。

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