肾上腺髓质素对大鼠脑微动脉的影响。

Effects of adrenomedullin on rat cerebral arterioles.

作者信息

Mori Y, Takayasu M, Suzuki Y, Shibuya M, Yoshida J, Hidaka H

机构信息

Department of Neurosurgery, Nagoya University School of Medicine, Showa, Japan.

出版信息

Eur J Pharmacol. 1997 Jul 9;330(2-3):195-8. doi: 10.1016/s0014-2999(97)01028-5.

DOI:10.1016/s0014-2999(97)01028-5

PMID:9253953

Abstract

The effects of adrenomedullin on isolated rat intracerebral arterioles were investigated and compared with those of calcitonin gene-related peptide (CGRP) and amylin. Adrenomedullin produced dose-dependent vasodilation (maximum dilation 27.1 +/- 2.1% at 3 x 10(-7) M, median effective dose (EC50)) 1.6 x 10(-9) M). CGRP produced similar vasodilation (19.8 +/- 4.1%) at 10(-7) M with a lower EC50 of 2.8 x 10(-11) M. Amylin did not cause vasodilation at concentrations up to 10(-6) M. Adrenomedullin-induced vasodilation was significantly suppressed by CGRP-(8-37). These data suggest that adrenomedullin is a potent vasodilator for arterioles in the cerebral microcirculation that acts through CGRP receptors.

摘要

研究了肾上腺髓质素对离体大鼠脑内小动脉的作用，并与降钙素基因相关肽（CGRP）和胰淀素进行了比较。肾上腺髓质素产生剂量依赖性血管舒张（在3×10⁻⁷M时最大舒张率为27.1±2.1%，半数有效剂量（EC50）为1.6×10⁻⁹M）。CGRP在10⁻⁷M时产生类似的血管舒张（19.8±4.1%），EC50较低，为2.8×10⁻¹¹M。胰淀素在浓度高达10⁻⁶M时未引起血管舒张。CGRP-（8-37）显著抑制肾上腺髓质素诱导的血管舒张。这些数据表明，肾上腺髓质素是脑微循环中小动脉的一种强效血管舒张剂，通过CGRP受体发挥作用。