Kondo M, Wang L, Bill A
Department of Physiology and Medical Biophysics, University of Uppsala, Sweden.
Acta Ophthalmol Scand. 1997 Jun;75(3):232-5. doi: 10.1111/j.1600-0420.1997.tb00762.x.
To elucidate the role of nitric oxide (NO) in the eye and the flicker-induced vascular response.
The blood flow in the retina and different parts of the optic nerve was compared in cats treated with the NO-synthase blocker, N(G)-nitro-L-arginine methyl ester and in control animals. In both groups, one of the eyes was dark-adapted, the other was subjected to 8 Hz flickering light. The regional blood flow was measured with the microsphere method.
In control animals, flickering light increased blood flow in the retina and optic nerve head by 39% and 256%, respectively. Pretreatment with N(G)-nitro-L-arginine methyl ester prevented this increase in retinal blood flow and markedly reduced the blood flow in the optic nerve heads.
NO release may mediate much of the vasodilating effect of flicker in cats, and play a role in maintaining normal vascular tone in the optic nerve head.
阐明一氧化氮（NO）在眼部及闪烁光诱导的血管反应中的作用。
比较用NO合酶阻滞剂N(G)-硝基-L-精氨酸甲酯处理的猫和对照动物视网膜及视神经不同部位的血流情况。两组动物中，一只眼睛进行暗适应，另一只眼睛接受8Hz闪烁光照射。用微球法测量局部血流。
在对照动物中，闪烁光使视网膜和视神经乳头的血流分别增加39%和256%。用N(G)-硝基-L-精氨酸甲酯预处理可阻止视网膜血流的这种增加，并显著降低视神经乳头的血流。
NO释放可能介导了猫眼中闪烁光的大部分血管舒张作用，并在维持视神经乳头的正常血管张力中发挥作用。
