Aguilar-Rebolledo F, Rendón-Macías M E, Escobar-Barrios E
Departamento de Neurología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F.
Gac Med Mex. 1997 Mar-Apr;133(2):63-70.
In Guillain-Barré syndrome (GBS) painful involvement has not been considered as a major clinical manifestation for diagnostic criteria among children. Was to evaluate whether clinical our purpose painful sensations are the main manifestations in pediatric patients with GBS. Twenty patients that fulfilled the Asbury criteria for diagnosis of GBS were studied prospectively from January, 1992 to June, 1994. Painful sensations were evaluated considering segmentary level with special focus in intensity, modality, topography distribution from the beginning to the resolution of the paralysis and effect to analgesic therapy every day for the first week and weekly thereafter. Patients had a mean age of 9.6 years (SD 5.4). Twelve patients were males and eight were females. All the patients but one complained of pain during some time of the course of illness, (19/20, 95%). At the illness onset, pain sensations were spontaneously referred in 12/20 (60%) of the cases, after anamnesis in 3/20 (15%) and physical exam in 4/20 (20%). Pain distribution during acme occurred in feet, thighs and legs in 95% of patients; back, arms and forearms in 65%, buttocks, shoulders and hands in 35%. The highest intensity of pain took place the first week of the illness course, and the mean time of decreasing occurred with a median of three days after onset with complete resolution three weeks later. We report that pain was an early and main clinical manifestation of GBS in children. We suggest that pain must be considered as a relevant criterium for GBS diagnosis in pediatric patients.
在吉兰-巴雷综合征(GBS)中,疼痛累及未被视为儿童诊断标准中的主要临床表现。我们的目的是评估临床疼痛感觉是否为GBS儿科患者的主要表现。对1992年1月至1994年6月期间符合阿斯伯里GBS诊断标准的20例患者进行了前瞻性研究。从麻痹开始到缓解,每天评估疼痛感觉,考虑节段水平,特别关注强度、形式、地形分布,并在第一周每天以及此后每周评估镇痛治疗的效果。患者的平均年龄为9.6岁(标准差5.4)。12例为男性,8例为女性。除1例患者外,所有患者在病程的某个时间段均主诉疼痛(19/20,95%)。在疾病发作时,12/20(60%)的病例自发出现疼痛感觉,3/20(15%)在问诊后出现,4/20(20%)在体格检查后出现。在病情高峰期,95%的患者疼痛分布在足部、大腿和小腿;65%分布在背部、手臂和前臂;35%分布在臀部、肩部和手部。疼痛强度在病程的第一周最高,疼痛减轻的平均时间中位数为发病后三天,三周后完全缓解。我们报告疼痛是儿童GBS的早期和主要临床表现。我们建议疼痛应被视为儿科患者GBS诊断的相关标准。