Segura Porta F, Moreno A, Serrate G, Claramonte X, Martos Rodríguez A, Mensa J, Ribot T, Sanfeliu I, Jiménez de Anta M T
Programa Asistencial de Enfermedades Infecciosas, Consorci Hospitalari del Parc Taulí, Sabadell.
Rev Clin Esp. 1997 Apr;197(4):241-4.
The empiric antibiotic therapy for acute gastroenteritis (AGE) is indicated only in patients with underlying diseases or risk for bacteremia. The clinical characteristics, clinical efficiency of antibiotic therapy with pivmecillinam (52 patients) or ciprofloxacin (75 patients) and its effects on the fecal carrier state of Salmonella spp. were studied in 127 adult patients with AGE and antibiotic therapy indication. The initial stool culture was positive in 90 patients (71%). The microorganism recovered most frequently was Salmonella spp., with a bacteremia rate in these patients of 5%. The susceptibility of Salmonella spp. to ciprofloxacin and mecillinam was 100% and 90%, respectively. Therapy with ciprofloxacin or pivmecillinam showed a similar efficiency. Fecal excretion lasted no longer than five weeks and no chronic carriers were observed.
急性胃肠炎（AGE）的经验性抗生素治疗仅适用于有基础疾病或有菌血症风险的患者。在127例有抗生素治疗指征的成年AGE患者中，研究了匹美西林（52例患者）或环丙沙星（75例患者）抗生素治疗的临床特征、临床疗效及其对沙门氏菌粪便携带状态的影响。90例患者（71%）的初始粪便培养呈阳性。最常分离出的微生物是沙门氏菌，这些患者的菌血症发生率为5%。沙门氏菌对环丙沙星和美西林的敏感性分别为100%和90%。环丙沙星或匹美西林治疗显示出相似的疗效。粪便排泄持续不超过五周，未观察到慢性携带者。
