[动物处于功能性应激状态时大鼠肝脏染色质中组蛋白的变化]
[Change in histone proteins in rat liver chromatin during exposure of the animal to functional stress].
作者信息
Panin L E, Svechnikova I G, Maianskaia N N
出版信息
Vopr Med Khim. 1996 Oct-Dec;42(4):295-300.
PMID:9254513
Abstract
Pattern of rat liver histones at intensive physical exercises with preliminary injection of lysosomotropic drugs was studied by method of electrophoresis in PAAG. Elevation of the acetylated forms of histone H4 was revealed. The increased proteolysis of lysine-rich histones (H1, H2A, H2B) was shown in swimming rats previously stimulated by prodigiosan. The possible role of lysosomal proteinases of liver cells in mechanism of chromatine activation is discussed.
摘要
采用聚丙烯酰胺凝胶电泳法研究了预先注射溶酶体促透药物后大鼠在剧烈体育锻炼时肝脏组蛋白的模式。发现组蛋白H4的乙酰化形式有所升高。在先前经灵菌红素刺激的游泳大鼠中，富含赖氨酸的组蛋白（H1、H2A、H2B）的蛋白水解增加。讨论了肝细胞溶酶体蛋白酶在染色质激活机制中的可能作用。
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