Klimenko A I, Malyshev A B, Kulachenko B V
Biokhimiia. 1986 Apr;51(4):553-61.
The metabolism of various classes of histones and nonhistone proteins in intact nuclei and in liver chromatin of albino Wistar rats aged 1, 3, 12 and 24 months, was studied. It was shown that in the course of postnatal development the metabolism of nonhistone proteins extracted with 0.14 M NaCl in murine liver is increased. Later in ontogenesis, the incorporation of labeled precursors into proteins HMG 14 and HMG 17 decreases; the specific radioactivity of proteins HMG 1 + 2 is higher in 3- and 24-month-old animals. The intensity of metabolism of nonhistone proteins and histones is higher within the composition of the chromatin complex than in the intact nucleus at all stages of postnatal development. Among other histone proteins, histones H1 are characterized by the highest level specific radioactivity in rats of all age groups.
研究了1、3、12和24月龄白化Wistar大鼠完整细胞核及肝脏染色质中各类组蛋白和非组蛋白的代谢情况。结果表明，在出生后发育过程中，用0.14M NaCl提取的小鼠肝脏非组蛋白的代谢增加。在个体发育后期，标记前体掺入HMG 14和HMG 17蛋白的量减少；HMG 1 + 2蛋白的比放射性在3月龄和24月龄动物中较高。在出生后发育的所有阶段，染色质复合物中非组蛋白和组蛋白的代谢强度均高于完整细胞核。在其他组蛋白中，H1组蛋白在所有年龄组的大鼠中具有最高水平的比放射性。
