Munan L, Kelly A, Petitclerc C
J Lab Clin Med. 1977 Dec;90(6):990-6.
Urate levels were assayed in sera of 292 subjects between 10 and 14 years of age identified through a probability sample of a natural population. The sex trends in serum urate concentrations characteristic of childhood were seen to continue into early adolescence, with girls maintaining slightly higher means. Between 10 and 14 years there was first an overlap of male and female values followed by a reversal of trends, with much higher means in boys. Serum urate concentrations peaked in girls at age 11 and gradually stabilized at lower levels. Boys, on the other hand, showed little age variation in serum urate at 10 and 11 years but by age 12 showed sharp upward trends which continued throughout adolescence. Since age and body weight are known to be important covariates of serum urate, boys were matched to girls of the same age and body weight. Significant sex differences in urate levels persisted (after matching) only for 14-year-old adolescents and thus at this age could not be ascribed to weight differentials. The study highlights a peripubertal phenomenon whose mechanism might be endocrine related.
通过对一个自然人群的概率样本进行筛选，测定了292名10至14岁受试者血清中的尿酸水平。儿童期血清尿酸浓度的性别趋势在青春期早期仍持续存在，女孩的平均水平略高。在10至14岁之间，男女尿酸值首先出现重叠，随后趋势逆转，男孩的平均水平更高。女孩的血清尿酸浓度在11岁时达到峰值，随后逐渐稳定在较低水平。另一方面，男孩在10岁和11岁时血清尿酸水平随年龄变化不大，但到12岁时呈急剧上升趋势，并在整个青春期持续。由于年龄和体重是血清尿酸的重要协变量，因此将男孩与相同年龄和体重的女孩进行匹配。（匹配后）尿酸水平的显著性别差异仅在14岁青少年中持续存在，因此在这个年龄段，这种差异不能归因于体重差异。该研究突出了一种青春期前后的现象，其机制可能与内分泌有关。
