Ries M
University Children's Hospital, Erlangen, Germany.
Semin Thromb Hemost. 1997;23(3):247-52. doi: 10.1055/s-2007-996097.
The blood fibrinolytic system essentially consists of proteolytic enzyme activation processes leading to the formation of the fibrin-degrading enzyme plasmin. It is thus the counterpart of the blood coagulation system. It differs physiologically in newborns compared with adults. In newborns, the plasma levels of plasminogen, the inactive plasmin precursor, are relatively low, and a correlation between maturity and plasminogen levels is observed. Newborn plasminogen has been purified, characterized, and compared with adult plasminogen and does exist in a fetal form with an increased concentration of sialic acid, similar to fetal fibrinogen. We review the molecular and functional properties of fetal plasminogen and its possible influence on clot lysis and thrombolytic therapy in the neonatal period.
血液纤维蛋白溶解系统主要由导致纤维蛋白降解酶纤溶酶形成的蛋白水解酶激活过程组成。因此，它是血液凝固系统的对应物。与成年人相比，新生儿的生理情况有所不同。在新生儿中，纤溶酶原（无活性的纤溶酶前体）的血浆水平相对较低，并且观察到成熟度与纤溶酶原水平之间存在相关性。新生儿纤溶酶原已被纯化、表征，并与成人纤溶酶原进行了比较，确实以胎儿形式存在，其唾液酸浓度增加，类似于胎儿纤维蛋白原。我们综述了胎儿纤溶酶原的分子和功能特性及其对新生儿期凝块溶解和溶栓治疗的可能影响。
