Nantulya V M, Musoke A J, Barbet A F, Roelants G E
J Parasitol. 1979 Oct;65(5):673-9.
Seven out of 11 bovines infected with different clones of Trypanosoma brucei showed 2 peaks of antibody activity against the infecting clone within 7 weeks, as measured by immunofluorescence, radioimmunoassay, and neutralization of infectivity tests. Using other clones from an unrelated Stock, antibodies to these clones were not detectable, indicating that the antibodies produced were specific to the infecting organisms. These results suggest that there was a reappearance or increase in numbers of the infecting organisms or of organisms with variable surface antigens similar to those of the infecting clones. The reappearance of variable antigen types in the presence of specific antibodies would imply that antibody plays a selective rather than an inductive role in the process of antigenic variation in African trypanosomes.
通过免疫荧光、放射免疫测定以及感染性中和试验检测发现，11头感染不同克隆布氏锥虫的牛中有7头在7周内出现了针对感染克隆的2个抗体活性峰值。使用来自无关虫株的其他克隆时，未检测到针对这些克隆的抗体，这表明所产生的抗体对感染生物具有特异性。这些结果表明，感染生物或具有与感染克隆相似可变表面抗原的生物数量出现了再次出现或增加。在存在特异性抗体的情况下可变抗原类型再次出现，这意味着抗体在非洲锥虫抗原变异过程中起选择性而非诱导性作用。
