Dimache G, Croitoru M, Dimache A
Cantacuzino Institute, Bucharest, Romania.
Roum Arch Microbiol Immunol. 1996 Jul-Sep;55(3):215-23.
Enteric vaccines are currently administered in man either orally or parenterally, each vaccination route having its advantages and disadvantages. In an attempt to cumulate the favourable effects of the two immunization methods a combined (oral-intradermal) anti-S.typhimurium and anti-S.typhi vaccination scheme was applied in mice. For comparison reasons, the oral (one or two immunization cycles) and the parenteral (one or two vaccine doses intradermally administered) vaccinations were used. The results obtained showed that mixed (oral-intradermal) vaccination induces a higher protective effect to infection with S.typhimurium or S.typhi, as compared to the single oral vaccination (one or two cycles) and a protective effect which does not differ from that obtained by intradermal vaccination.
目前，肠道疫苗在人体中通过口服或肠胃外途径给药，每种接种途径都有其优缺点。为了累积两种免疫方法的有利效果，在小鼠中应用了联合（口服-皮内）抗鼠伤寒沙门氏菌和抗伤寒沙门氏菌的疫苗接种方案。出于比较的目的，采用了口服（一个或两个免疫周期）和肠胃外（皮内注射一或两剂疫苗）接种方式。获得的结果表明，与单次口服接种（一个或两个周期）相比，混合（口服-皮内）接种对鼠伤寒沙门氏菌或伤寒沙门氏菌感染具有更高的保护作用，且其保护作用与皮内接种所获得的保护作用无差异。
