对从不同病理状态分离出的部分肺炎链球菌菌株对抗菌药物敏感性的研究。

Study of the sensitivity to antimicrobial drugs of some S. pneumoniae strains isolated from different pathological states.

作者信息

Ungureanu V, Pană M, Gheorghe M, Mihalcu F, Dorobăţ O, Mitache E, Lucinescu S T, Vrînceanu L

机构信息

Cantacuzino Institute, Bucharest, Romania.

出版信息

Roum Arch Microbiol Immunol. 1996 Jul-Sep;55(3):241-51.

PMID:9256025

Abstract

76 Str.pneumoniae strains isolated from different clinical disease forms were studied for the sensitivity to antimicrobial drugs using the diffusimetric method and the dilution in agar method (MIC to penicillin). The results revealed that 44.74% of pneumococci were sensitive to penicillin, the remaining pneumococci being resistant; 18.42% showed a high resistance (MIC > or = 2 micrograms/ml). A close relationship was seen between sensitivity to penicillin on the one hand and the Pneumococcus origin and serotype on the other. As concerning the multiresistance to antimicrobial drugs, 47.4% of the strains presented resistance to > or = antibiotics belonging to different classes, the most frequent resistance pattern being P, E, Te, SxT. The most active antimicrobial drugs were vancomycin, amoxiclave, rifampicin, followed by ceftriaxone and amoxicillin.

摘要

采用扩散法和琼脂稀释法（青霉素最低抑菌浓度），对从不同临床疾病形式中分离出的76株肺炎链球菌进行了抗菌药物敏感性研究。结果显示，44.74%的肺炎球菌对青霉素敏感，其余肺炎球菌耐药；18.42%表现出高度耐药（最低抑菌浓度≥2微克/毫升）。一方面，对青霉素的敏感性与肺炎球菌的来源和血清型之间存在密切关系。至于对抗菌药物的多重耐药性，47.4%的菌株对≥属于不同类别的抗生素耐药，最常见的耐药模式是对青霉素、红霉素、四环素、复方新诺明耐药。最具活性的抗菌药物是万古霉素、阿莫西林克拉维酸、利福平，其次是头孢曲松和阿莫西林。