Brizuela B J, Kennison J A
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Mech Dev. 1997 Jul;65(1-2):209-20. doi: 10.1016/s0925-4773(97)00081-6.
moira is a member of the trithorax group of homeotic gene regulators in Drosophila melanogaster. We show that moira is required for the function of multiple homeotic genes of the Antennapedia and bithorax complexes (HOM genes) in most imaginal tissues and that the requirement for moira function is at the level of transcription. moira is also required for transcription of the engrailed segmentation gene in the imaginal wing disc. The abnormalities caused by the loss of moira function in germ cells suggests that at least one other target gene requires moira for normal oogenesis.
莫伊拉是黑腹果蝇同源异型基因调控因子三胸复合体的成员。我们发现，在大多数成虫盘组织中，莫伊拉是触角足复合体和双胸复合体（HOM基因）的多个同源异型基因功能所必需的，并且对莫伊拉功能的需求处于转录水平。在成虫翅盘中，莫伊拉也是 engrailed 分节基因转录所必需的。生殖细胞中莫伊拉功能丧失所导致的异常表明，至少还有一个其他靶基因在正常卵子发生过程中需要莫伊拉。
