Giannitsis D J
J Clin Chem Clin Biochem. 1977 Sep;15(9):509-11. doi: 10.1515/cclm.1977.15.1-12.509.
The human leukocyte nuclear histones can bind to haptoglobin (Hp), and thus interfere with subsequent binding of Hb. The Hp/Hb complex possesses peroxidase activity, but a Hp/histone complex does not. The inhibitory effect of histone molecules depends directly on the Hp and Hb, as well as the histone concentrations. The biological significance of the complex Hp/Hb as a measure of intravascular hemolysis and the interference of histones in this assay is briefly discussed.
