Smith A, Harbour D, Liebmann J
University of New Mexico Cancer Research and Treatment Center, Albuquerque 87131, USA.
Am J Clin Oncol. 1997 Aug;20(4):433-4. doi: 10.1097/00000421-199708000-00024.
Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials. We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin. Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment. Acute renal failure should be recognized as a potential complication of suramin treatment.
苏拉明已显示出对前列腺癌有一定活性，目前正在进行临床试验研究。我们描述了一名转移性前列腺癌患者，在接受苏拉明治疗期间发生了非少尿型肾衰竭。我们的患者不存在肾衰竭的其他潜在病因，且随着苏拉明治疗的停止，其肾功能逐渐恢复。急性肾衰竭应被视为苏拉明治疗的一种潜在并发症。
