Baer G M
Laboratorios Baer, SA de CV, Mexico DF, Mexico.
Am J Vet Res. 1997 Aug;58(8):837-40.
To evaluate the potency of an inactivated animal rabies vaccine for domestic animals by use of 2 types of potency tests after challenge exposure with a laboratory standard virus or 1 of 5 viruses obtained from various wildlife species.
384 mice vaccinated twice intraperitoneally; 384 mice vaccinated once IM.
Mice vaccinated with an inactivated, adjuvanted rabies vaccine for domestic animals were challenge exposed with the common fixed challenge virus or 1 of 5 rabies viruses obtained from wild animal species (street viruses) that most commonly transmit the virus in the United States and Canada. Potency tests included 2 types of antigen extinction tests: the National Institutes of Health (NIH) test and the Centers for Disease Control test.
Results of both tests indicated that protection was highest against raccoon and bat viruses. Marked differences were detected in the relative potency ratios for the NIH versus the Centers for Disease Control tests, though the relative potencies themselves (against the street viruses) did not differ markedly.
The markedly reduced potency against the street viruses indicated by the NIH test results was suggestive of an inherent bias associated with double intraperitoneal vaccination and intracerebral challenge exposure, whereas the single IM vaccination and IM challenge exposure reduced that bias.
通过在接种实验室标准病毒或从5种野生动物病毒中获取的1种病毒（从各种野生动物物种中获得）后使用2种效力测试方法，评估一种用于家畜的灭活动物狂犬病疫苗的效力。
384只小鼠经腹腔注射接种两次；384只小鼠经肌肉注射接种一次。
用一种用于家畜的灭活佐剂狂犬病疫苗接种的小鼠，经普通固定攻击病毒或从美国和加拿大最常传播该病毒的野生动物物种中获得的5种狂犬病病毒（街毒）之一进行攻击暴露。效力测试包括2种抗原灭活测试：美国国立卫生研究院（NIH）测试和疾病控制中心测试。
两种测试结果均表明，对浣熊和蝙蝠病毒的保护作用最高。尽管NIH测试和疾病控制中心测试的相对效力本身（针对街毒）没有显著差异，但在相对效力比方面检测到显著差异。
NIH测试结果表明对街毒的效力显著降低，这表明与腹腔内两次接种和脑内攻击暴露相关的固有偏差，而单次肌肉注射接种和肌肉注射攻击暴露减少了该偏差。
