Heath H L, Blagburn B L, Elsasser T H, Pugh D G, Sanders L G, Sartin E A, Steele B, Sartin J L
Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA.
Am J Vet Res. 1997 Aug;58(8):891-6.
To determine whether an estradiol-progesterone (EP) growth implant would have an effect on febrile responses and on the catabolic component of Eimeria bovis infection.
27 Holstein bull calves.
Calves were assigned to treatment groups as: control (n = 5), EP implant (EP, n = 5), E bovis-inoculated (coccidia: C, n = 7), pair fed (n = 4), or EP plus E bovis-inoculated coccidia (EP/C, n = 6) groups. Calves were provided subcutaneous EP implants at 8 weeks of age, and were inoculated with 2 x 10(5) oocysts of E bovis at 11 weeks of age. Body weight was measured on postinoculation day (PID) 0, 14, and 28. Rectal temperature and food intake were determined and fecal samples were collected daily from PID 15 to 28. Blood samples were collected on PID 24 for analysis of CD2+, CD4+, and CD8+ antigens and plasma insulin-like growth factor I concentration. Blood samples were collected at 15-minute intervals for measurement of pulsatile growth hormone release.
Group-EP/C calves had fever for 2 days versus 5 days for group-C calves (P < 0.05). These calves had diarrhea for fewer days than did their group-C counterparts (P < 0.05). Fibrinogen and glucose values were high in group-C (P < 0.05) but not group-EP/C calves. The latter had positive weight gain from PID 14 to 28, whereas group-C calves had weight loss (P < 0.05). Plasma insulin-like growth factor I concentration was reduced by infection (P < 0.05). EP-treated noninfected calves had increased numbers of CD2+, CD4+, and CD8+ blood mononuclear cells (P < 0.05).
EP has a protective effect in calves infected with E bovis. This may relate to changes in immune function induced by EP.
Treatment of calves with EP could offer some protection against the often severe wasting and debilitation associated with E bovis infection.
确定雌二醇 - 孕酮（EP）生长植入物是否会对发热反应以及牛艾美耳球虫感染的分解代谢成分产生影响。
27头荷斯坦公牛犊。
将犊牛分为以下治疗组：对照组（n = 5）、EP植入组（EP，n = 5）、牛艾美耳球虫接种组（球虫：C，n = 7）、配对饲养组（n = 4）或EP加牛艾美耳球虫接种组（EP/C，n = 6）。犊牛在8周龄时皮下植入EP，在11周龄时接种2×10⁵个牛艾美耳球虫卵囊。在接种后第0、14和28天测量体重。从接种后第15天至28天每天测定直肠温度和采食量，并收集粪便样本。在接种后第24天采集血样，用于分析CD2⁺、CD4⁺和CD8⁺抗原以及血浆胰岛素样生长因子I浓度。每隔15分钟采集血样，用于测量脉冲式生长激素释放。
EP/C组犊牛发热2天，而C组犊牛发热5天（P < 0.05）。这些犊牛腹泻天数比C组对应犊牛少（P < 0.05）。C组纤维蛋白原和葡萄糖值较高（P < 0.05）而EP/C组犊牛则不然。后者在接种后第14天至28天体重呈正增长，而C组犊牛体重下降（P < 0.05）。感染使血浆胰岛素样生长因子I浓度降低（P < 0.05）。经EP处理的未感染犊牛血液中CD2⁺、CD4⁺和CD8⁺单核细胞数量增加（P < 0.05）。
EP对感染牛艾美耳球虫的犊牛有保护作用。这可能与EP诱导的免疫功能变化有关。
用EP治疗犊牛可为预防通常与牛艾美耳球虫感染相关的严重消瘦和衰弱提供一定保护。
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