Moerlein S M, Perlmutter J S, Cutler P D, Welch M J
Edward Mallinckrodt Institute of Radiology, St. Louis, MO 63110, USA.
Nucl Med Biol. 1997 May;24(4):311-8. doi: 10.1016/s0969-8051(97)00042-5.
Radiation absorbed doses due to IV administration of 18F benperidol ([18F]NMB) were estimated by whole-body PET imaging of nonhuman primates. Time-activity curves were obtained for nine compartments (striatum, eyes, heart, lungs, liver, gallbladder, intestines, kidneys, bladder) by using dynamic PET scans of three different baboons given the radiotracer. These time-activity curves were used to calculate the residence times of radioactivity in these tissues. Human absorbed dose estimates were calculated using the updated MIRDOSE 3 S values and assuming the same biodistribution. Based on an average of three studies, the critical organs were the lower large intestine, gallbladder, and liver, receiving doses of 585, 281, and 210 mrad/mCi, respectively. The brain received a dose of 13 mrad/mCi; other organs received doses between 32-77 mrad/mCi. These results indicate that up to 8.5 mCi of [18F]NMB can be safely administered to human subjects for PET studies of D2 receptor binding.
通过对非人灵长类动物进行全身正电子发射断层扫描（PET）成像，估算了静脉注射[18F]（N-甲基）苯哌利多（[18F]NMB）后的辐射吸收剂量。通过对三只不同狒狒进行放射性示踪剂的动态PET扫描，获得了九个部位（纹状体、眼睛、心脏、肺、肝脏、胆囊、肠道、肾脏、膀胱）的时间-活度曲线。这些时间-活度曲线用于计算放射性在这些组织中的停留时间。使用更新后的MIRDOSE 3 S值并假设生物分布相同，计算人体吸收剂量估计值。基于三项研究的平均值，关键器官为降结肠、胆囊和肝脏，吸收剂量分别为585、281和210毫拉德/毫居里。大脑的吸收剂量为13毫拉德/毫居里；其他器官的吸收剂量在32-77毫拉德/毫居里之间。这些结果表明，对于D2受体结合的PET研究，向人体受试者安全注射高达8.5毫居里的[18F]NMB是可行的。
