地塞米松会抑制人类神经胶质瘤的生长吗？
Does dexamethasone inhibit the growth of human gliomas?
作者信息
Sherbet G V, Lakshmi M S, Haddad S K
出版信息
J Neurosurg. 1977 Dec;47(6):864-70. doi: 10.3171/jns.1977.47.6.0864.
Dexamethasone (10-(4)M) was shown to inhibit the growth of human gliomas in culture. This was indicated by the inhibition of incorporation of radioactively labeled thymidine into the deoxyribonucleic acid (DNA) of the cells, and by the increase in the generation time of cells exposed to the drug in vitro. On the other hand, tumors obtained from patients who had received dexamethasone before craniotomy grew considerably faster in vitro than tumors from patients who had not been given the drug before operation.
地塞米松（10⁻⁴M）在培养中可抑制人类胶质瘤的生长。这通过抑制放射性标记的胸苷掺入细胞的脱氧核糖核酸（DNA）以及体外暴露于该药物的细胞倍增时间增加得以表明。另一方面，开颅术前接受过地塞米松治疗的患者所患肿瘤在体外生长速度比术前未接受该药物治疗的患者的肿瘤快得多。
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