Kato A, Ozawa F, Saitoh Y, Hirai K, Inokuchi K
Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan.
FEBS Lett. 1997 Jul 21;412(1):183-9. doi: 10.1016/s0014-5793(97)00775-8.
We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
我们分离出了一种新的cDNA，即vesl，它是在大鼠海马体惊厥发作期间被诱导产生的。vesl基因编码一种由186个氨基酸组成的蛋白质，该蛋白质与参与微丝动力学控制的VASP/Ena家族蛋白质的EVH1结构域具有显著同源性。在齿状回的持续性长时程增强（LTP）过程中，vesl mRNA的表达以NMDA受体依赖的方式在颗粒细胞层中被诱导。此外，vesl mRNA在海马体突触形成过程中高水平表达。我们认为，Vesl蛋白可能参与了在持久的神经元可塑性和发育过程中突触处发生的结构变化。
