金黄色葡萄球菌天然瓣膜心内膜炎的豚鼠模型
Guinea pig model for Staphylococcus aureus native valve endocarditis.
作者信息
Maurin M, Lepidi H, La Scola B, Feuerstein M, Andre M, Pellissier J F, Raoult D
机构信息
Unité des Rickettsies, CNRS EP J0054, Faculté de Médecine, CHU Timone, Marseille, France.
出版信息
Antimicrob Agents Chemother. 1997 Aug;41(8):1815-7. doi: 10.1128/AAC.41.8.1815.
Abstract
We present a new experimental model of Staphylococcus aureus infective endocarditis in guinea pigs. Permanent aortic valve damage was produced by electrocoagulation after catheterization of the right carotid artery, which allowed avoidance of the intracardiac catheter to produce cardiac vegetations. Our model closely mimics pathological mechanisms of native valve endocarditis.
摘要
我们提出了一种新的豚鼠金黄色葡萄球菌感染性心内膜炎实验模型。在右颈动脉插管后通过电凝造成永久性主动脉瓣损伤，这样可避免心内导管产生心脏赘生物。我们的模型紧密模拟了天然瓣膜心内膜炎的病理机制。
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