Eissa M M, Younis L K, Badawy E A
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
J Egypt Soc Parasitol. 1997 Aug;27(2):539-52.
Leishmania strain was isolated from a human case of cutaneous leishmaniasis and inoculated into experimental animals. Group of infected animals were given Dapsone, at a dose of 25 mg/kg for 3 weeks. Results showed that infected animals suffered from autoamputation of the inoculated foot pad. On the other hand, those receiving Dapsone showed complete clinical cure. Transmission Electron Microscope of both groups revealed the fine structure of Leishmania amastigotes. Those given Dapsone showed considerable reversible changes which didn't affect parasitic virulence. This latter has been demonstrated by their ability to infect experimental animals. leading to pathological lesion. It should be pointed out that patients treated with this drug and showed marked clinical response must be very carefully examined for fear of residual parasites which may be the cause of relapse later on.
利什曼原虫菌株从一例皮肤利什曼病患者中分离出来，并接种到实验动物体内。感染动物组给予氨苯砜，剂量为25毫克/千克，持续3周。结果显示，感染动物接种的足垫出现自截。另一方面，接受氨苯砜治疗的动物临床完全治愈。两组的透射电子显微镜观察揭示了利什曼原虫无鞭毛体的精细结构。接受氨苯砜治疗的动物显示出相当大的可逆性变化，但不影响寄生虫的毒力。这一点已通过它们感染实验动物并导致病理损伤的能力得到证明。应该指出的是，用这种药物治疗且有明显临床反应的患者必须非常仔细地检查，以防残留寄生虫，这些残留寄生虫可能是日后复发的原因。
